15 de janeiro de 2018
15 de janeiro de 2018

Psychotherapy and Neuroscience: toward closer integration

The original aim of psychology was to study and understand the spirit—from the Latin spiritus, literally
‘‘breath.’’ The limitations of scientific methods in the past favoured psychology’s aloofness in terms of
studying the ‘‘intangible,’’ while medicine developed methods of examining the body (Latin corpus: essential
part). Until 20 years ago, knowledge of the localization of brain functions was limited to inferences from clinical
observation of brain-lesioned patients or parallel studies of primate brains. Current neuroscience, with its
integrative approach, is bringing together research from molecular through cognitive levels, and psychotherapy
has benefited from these findings. Functional neuroimaging studies may make specific and more far-reaching
contributions in this respect, since cerebral dynamics may be observed in vivo and in controlled situations.
Methods such as single photon emission tomography, positron emission tomography, and functional magnetic
resonance imaging have been able to evaluate the neural correlates involved in psychotherapy for individuals with
obsessive-compulsive disorder, major depression, social phobia, specific phobia, and post-traumatic disorder.
Researchers have found that psychotherapy has the potential to modify dysfunctional neural circuits associated
with these disorders. However, precautions are required in constructing feasible designs for neurofunctional
investigations. This article reviews the 21 studies that have been published on the subject, and sets out the main
advantages and limitations of the technologies used most frequently in protocols involving psychotherapies, and
prerequisites for experimental designs. We also pose ways in which the findings from neuroimaging may produce
knowledge to guide psychotherapeutic interventions by specifying what should be stimulated in these individuals
in order to normalize deficient neural activities.